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May 2014 - Posts

David Plaut: Off the Cuff

Cancer and the Immune System
May 28, 2014 3:46 PM by David Plaut
Immunotherapy for cancer has unde rgone a renaissance in recent years, based both on technological developments such as the ease in introducing genes into T cells and on an improved understanding of the obstacles to eradicating cancer through immune mechanisms. Read More...
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The Biology and Genetics of Obesity
May 22, 2014 1:46 PM by David Plaut
Many years ago, I came up with a sure way to lose weight – take in fewer calories than you burn. What could be simpler? I was not alone. A study of more than 1100 adults found that 61% of U.S. adulates that “personal choices about eating and exercise” Read More...
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A Diagnostic Algorithm for Suspected Upper-Extremity Deep Venous Thrombosis
May 20, 2014 2:02 PM by David Plaut
The prevalence of upper-extremity deep venous thrombosis (DVT) has risen in conjunction with more frequent use of central venous catheters. There are clear algorithms for diagnosing lower-extremity (e.g. Wells), but not for upper-extremity, DVT. A multicenter Read More...
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Mammography Screening, Part 2
May 13, 2014 12:45 PM by David Plaut
This is the second of two blogs in which I discuss a response to the Swiss Medical Boards recommendation to stop mammography screening for breast cancer. In a separate essay, two of the members of the committee that wrote the recommendation brought up Read More...
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Mammography Screening: To Screen or Not to Screen?
May 8, 2014 1:29 PM by David Plaut
Recently, the Swiss Medical Board proposed discontinuing screening of women for breast cancer using mammography. The report did not suggest an alternate. The board included a medical ethicist, a clinical epidemiologist, a clinical pharma-cologist, an Read More...
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A New Supply of Blood?
May 6, 2014 2:17 PM by David Plaut
It is possible that, in two to three years, we may have a new source of blood. Studies from U. Edinburgh and the Scottish National Blood Transfusion Service have been able to reprogrammed red cells grown from fibroblasts into mature red cells. This blood Read More...
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An Intriguing Story of the Evolution of a Group A Streptococcus
May 1, 2014 2:51 AM by David Plaut
The ability to determine the entire genome of bacteria has led to the identification of how a harmless bacteria in only 4 steps became a deadly, widely appearing clone. Step 1 was that the precursor cell contained a phage that encoded an extracellular Read More...
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