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David Plaut: Off the Cuff

Biomarkers for Acute Kidney Injury

Published July 1, 2014 11:28 AM by David Plaut

The kidney has a remarkable capacity to withstand insults for an extended period of time. The sensitivities of individual renal cells to injury vary depending on their type, position in the nephron, local vascularization, and the nature of injury. The resulting kidney injury is a product of the interplay between cell dysfunction, cell death, proliferation, inflammation, and recovery.

Acute kidney injury (AKI) is a common and serious condition in both the inpatient and outpatient settings, and its diagnosis depends on serum creatinine or cystatin C measurements.

Unfortunately, creatinine is a delayed and unreliable indicator of AKI. The lack of early biomarkers has limited our ability to translate promising experimental therapies to human AKI. Fortunately, understanding the early stress response of the kidney to acute injuries has provided a number of potential biomarkers. For example, neutrophil gelatinase-associated lipocalin (NGAL) is emerging as an excellent stand alone biomarker in the plasma and urine for predicting and monitoring clinical trials and in the prognosis of AKI. In recent years, a number of new biomarkers of AKI with more favorable test characteristics.

The two tables indicate the utility of the newer markers, some of which are commercially available indicate the utility of these markers compared to cystatin C.  Because the pattern of appearance in the urine or serum, varies with the markers it may be necessary to use more than one marker to detect and monitor AKI.

Efforts to detect AKI in the earlier stage has resulted in some promising biomarkers such as KIM-1, NGAL, IL-18, and Clusterin. Cystatin C is a biomarker for glomerular filtration function, while 2-microglobulin, 1-microglobulin, NAG, RBP, IL-18, NGAL, Netrin-1, KIM-1, Clusterin, Sodium Hydrogen Exchanger Isoform and Fetuin A are biomarkers for tubular reabsorption function.

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This is very interesting research! Please contact me sometime to discuss it further.

Ann Aiken, Elementary - Teacher, Marsh Pointe Elem. July 5, 2014 8:48 PM
Palm Beach Gardens FL

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