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David Plaut: Off the Cuff

Test Development: Why Some Tests Fly and Others Flop
November 9, 2009 2:59 PM by David Plaut
Why do some diagnostic tests that seem useful to clinicians in their infancy never fully develop into stars? A number of reasons should be kept in mind when working with a new test in your laboratory or just reading an article or listening to a vendor. Read More...
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Reference Range Headaches
October 26, 2009 1:23 PM by David Plaut
I was recently asked to give a lecture on establishing a reference range. For me, this is an easy task on paper but a difficult task to carry out. By reference range I mean that range from a low value to a high value within which most “normal” people Read More...
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Case Studies: What's Your Dx?
October 19, 2009 12:25 PM by David Plaut
What's the diagnosis? Answer: diabetic ketoacidosis Another one: Answer: Non-thyroidal illness. Normal cortisol suggests no issue of the hypothalamus-pituitary-thyroid axis. Read More...
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PSA Progress
September 21, 2009 12:21 PM by David Plaut
Prostate cancer (PCa) remains the second leading cause of cancer deaths in the U.S. as in most Western societies. Most men with PCa will not die from the disease but with it. Since the mid-1980s, screening with the prostate-specific antigen (PSA) blood Read More...
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Serum Biochemical Markers of Acute Pancreatitis
July 30, 2009 12:59 PM by David Plaut
Acute pancreatitis usually occurs as a result of alcohol abuse or bile duct obstruction. A careful review of the patient's history and appropriate laboratory studies can help the physician identify the etiology of the condition and guide management. Prompt Read More...
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Utility of Lp-PLA2
June 8, 2009 11:33 AM by David Plaut
A number of recent studies have demonstrated a major role for inflammation in atherogenesis, the pathophysiology of vulnerable plaque and, consequently, of cardiovascular events. Circulating markers of inflammation (e.g., CRP as measured by an hs-method Read More...
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BNP Testing and Clinical Outcomes
April 13, 2009 1:56 PM by David Plaut
From Annals of Internal Medicine: At two Australian teaching hospital emergency departments, 612 consecutive patients who presented with acute severe shortness of breath were assigned through randomized numbers to receive BNP testing (n = 306) or no testing Read More...
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Glycemic Control: The Utility of Hemoglobin A1c
August 12, 2008 1:18 PM by David Plaut
As sugar comsumption continues to rise and adult and childhood obesity and diabetes become more common, it seems imperative that the laboratory aid in monitoring and controlling blood glucose levels. I bring to your attention some recent material on both Read More...
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