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Stepwise Success

Is PCR Ready for Small Labs?

Published May 2, 2016 6:36 AM by Scott Warner

What is true for big labs eventually becomes true for small labs, mostly because volume discounts drive affordability. This is most recently true for PCR, a technology that has arrived in small laboratories for two platforms, the Meridian Illumigene and Nanosphere Verigene.

But is PCR ready for small labs?

I’m intrigued by this technology, and I can easily imagine it playing a role in small laboratories. This kind of platform offers rapid, definitive testing for infectious agents such as C. diff, pertussis, and bacterial agents in blood culture specimens. Testing a stool specimen for the C. diff toxin can eliminate the need for GDH antigen testing that detects non-toxin producing strains. Identifying bacteria sooner in a blood culture can give the physician a 24-hour head start. In theory this faster turnaround time with better results will reduce length of stay and assist antibiotic stewardship programs.

I wonder.

One reason I’m on the fence is expense. It’s great to claim that a new instrument will reduce length of stay, but bean counters aren’t impressed by soft cost savings that can’t really be quantified. Unless one is testing for something completely new that changes a protocol - the introduction of BNP comes to mind - it can be hard to convince bean counters that a faster turnaround time equals fewer inpatient days.

Another reason is wondering how having these results will change treatment. Clinicians embrace technology at different rates. How many of you are still running cardiac troponin and CKMB, for example? How many are still reporting percentile differentials with absolutes? How many are still performing more ESRs than CRPs? It sounds great to me to give the docs a better, faster result, but clinicians have to buy into new technology and use it to its potential. As primary information consumers they always drive demand for technology.

Finally - and this is a big reason - new platforms with radically different technology require a lot of training and competency assessment to get off the ground. In a small lab staffing is often sparse, raising questions such as, “What happens on weekends?” and “What happens when a doc wants it done STAT in the middle of the night?” The advantages of rapid PCR testing imply STAT requests, after all. Labs with squeezed budgets and payroll will have a difficult time fitting anything new and different into their menus, no matter how wonderful. It all takes time, money, attention to detail, and bodies to run the tests. In the current healthcare climate it can be hard enough just to get the bread and butter tests done in a timely fashion as more and more labs adopt a rapid response model.

I don’t know the answer, but I don’t hear physicians beating down the door for in-house PCR just yet.

I’m interested in how this technology has affected your laboratory. Has it lived up to the hype, and what problems have you encountered? Is it worth the expense?

NEXT: Slide Review or Manual Diff?

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About this Blog


    Scott Warner, MLT(ASCP)
    Occupation: Laboratory Manager
    Setting: Critical Access Hospital
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