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Aesthetics Practice Today

Are Botox Injections On Their Way Out?

Published December 6, 2011 7:05 AM by Cindy Cobb
A novel topical gel formulation of botulinum toxin type A is now in the developmental pipeline, and it may expand the range of cosmetic problems that can be tackled with the botulinum toxins. The topical gel, called RT001, is being developed by Revance Pharmaceuticals. It combines botulinum toxin type A with a proprietary carrier peptide that can transport the neurotoxin across the skin all the way down to the musculature. Even without an injection, patients can experience results that are similar to what we see with Botox Cosmetic (onabotulinumtoxinA) or Dysport (abobotulinumtoxinA). It is currently being studied for the treatment of crow's feet. The gel is in clinical trials (Phase II) and not yet approved by the Food and Drug Administration.

If the topical gel were eventually to win approval, how might it fit into clinical practice? Certainly some patients dislike needles so much that they would prefer to sit in an office with a gel on their skin for 20 to 30 minutes rather than get a 3-second injection and be on their way. But how many patients fit this profile? Think hyperhidrosis, for example. It would be nice to just rub a gel on and then wipe off using a simple proprietary cleansing procedure instead of injecting someone 25 times in the axilla.

Last year in the United States, 2.8 million injections of neurotoxins were performed, and more than 20,000 practitioners injected Botox. Sales of injectable neurotoxins are forecast to increase by more than 15% annually, according to the literature. This unique, painless product could greatly expand the patient population for wrinkle reduction by offering a highly effective treatment option.


Thanks John for setting the record straight.  

My error for not looking at the most recent statistics...or rather the source I used didn't use the most recent statistics.  

I appreciate you updating all blog followers regarding the number of injections.  Needless to say, the number continues to grow and aesthetics is a rapidly growing field.

The topical toxin remains unapproved by the FDA and until it is will be unavailable for use by most practitioners.  Let's hope that will occur soon to provide options for practitioners.

Cindy Cobb, Aesthetics - Nurse Practitioner, Allure Enhancement Center December 9, 2011 8:26 AM
Lafayette LA

Ms Cobb needs to get her facts straight before posting such information.

The product mentioned has been around for years.  There seem to be delays in the next stage of clinical trials but we don't know why.

Take a look at the American Society of Plastic Surgeons for real data on how many botulinum toxin injections took place last year - 5.4 million.

Check your facts!

John December 8, 2011 3:58 PM

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About this Blog

    Occupation: Physician Assistant/Nurse Practitioner
    Setting: Miami & Upland, Calif.
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