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Aesthetics Practice Today

Skin Rejuvenation at the Genetic Level

Published February 19, 2013 1:04 PM by Mina Grasso
Intense pulsed light - photorejuvenation - has been around for over 20 years.  It has grown rapidly in popularity over the last decade.

It is the most popular non-ablative skin rejuvenation treatment that has continued to show clinical improvement of skin quality with little to no downtime, hence the name "Fotofacial."

With a series of treatments, patients can experience the following:

  • Healthier, smoother skin
  • Reduced redness and flushing
  • Reduced pore size
  • Reduced fine lines and wrinkles
  • Reduced sun damage
  • A more youthful look
  • More even skin tone
  • Increased self-confidence
  • Increased collagen bundles

Recently a pilot study conducted by Anne Lynn S. Chang M.D. et al.  showed evidence of rejuvenation at the genetic level. "Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment" is published in the Journal of Investigative Dermatology (2013) 133, 394-402; doi:10.1038/jid.2012.287; published online 30 August 2012.

Study participants were treated with a series of 3 treatments on the forearm of broadband light (BBL), 4 weeks apart. Skin biopsies used to obtain genetic material were taken from the participant's treated area and a variety of comparisons were made to the adjacent non-treated area. 

The researchers used gene-sequencing technology to examine the effects of BBL on skin aging. BBL is also known as IPL - Intense Pulse Light or photo rejuvenation. They found that skin aging was associated with a significantly altered gene expression level, which became "rejuvenated" after a series of BBL treatments. The skin biopsies taken from the areas treated with BBL showed gene expression level more similar to youthful skin. 

This gives us a better understanding of what happens on the molecular level of skin rejuvenation using broadband light  (BBL, IPL). A series of photorejuvenation treatments can restore the gene expression pattern of skin aged due to intrinsic genetics or environmental factors and will then resemble younger skin.

Gene sequencing is new technology that will continue to help researchers learn more about the aging process of human skin and can now be used to show the miracle transformation of skin using Intense Pulsed Light - hotorejuvention.


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About this Blog

    Occupation: Physician Assistant/Nurse Practitioner
    Setting: Miami & Upland, Calif.
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