Skin Rejuvenation at the Genetic Level
Intense pulsed light - photorejuvenation - has been around
for over 20 years. It has grown rapidly
in popularity over the last decade.
It is the most popular non-ablative skin rejuvenation
treatment that has continued to show clinical improvement of skin quality with
little to no downtime, hence the name "Fotofacial."
With a series of treatments, patients can experience the
Healthier, smoother skin
Reduced redness and flushing
Reduced pore size
Reduced fine lines and wrinkles
Reduced sun damage
A more youthful look
More even skin tone
Increased collagen bundles
Recently a pilot study conducted by Anne Lynn S. Chang M.D.
et al. showed evidence of rejuvenation
at the genetic level. "Rejuvenation of Gene Expression Pattern of Aged Human
Skin by Broadband Light Treatment" is published in the Journal of Investigative Dermatology (2013) 133, 394-402;
doi:10.1038/jid.2012.287; published online 30 August 2012.
were treated with a series of 3 treatments on the forearm of broadband light
(BBL), 4 weeks apart. Skin biopsies used to obtain genetic material were taken
from the participant's treated area and a variety of comparisons were made to
the adjacent non-treated area.
The researchers used gene-sequencing technology to examine
the effects of BBL on skin aging. BBL is also known as IPL - Intense Pulse
Light or photo rejuvenation. They found that skin aging was associated with a
significantly altered gene expression level, which became "rejuvenated" after a
series of BBL treatments. The skin biopsies taken from the areas treated with
BBL showed gene expression level more similar to youthful skin.
This gives us a better understanding of what
happens on the molecular level of skin rejuvenation using broadband light (BBL, IPL). A series of photorejuvenation
treatments can restore the gene expression pattern of skin aged due to intrinsic
genetics or environmental factors and will then resemble younger skin.
sequencing is new technology that will continue to help researchers learn more
about the aging process of human skin and can now be used to show the miracle
transformation of skin using Intense Pulsed Light - hotorejuvention.