Natural Beauty Utilizing Platelet Rich Plasma
The number of ways to improve one's appearance is ever-increasing. The spectrum includes efficacious medical non-surgical procedures such as therapeutic skin care regimens, laser rejuvenation with non-ablative and ablative lasers and liquid facelifts incorporating a combination of neuromodulator and tissue fillers. Natural-appearing beauty is the desire of many. The other end of the medical spectrum involves surgical approaches such as facelifts, which although often flattering, can change a person's appearance.
The buzz, fascination and growing popularity with platelet rich plasma (PRP) is related to the ongoing search for natural beauty. Platelet rich plasma allows a patients' own regenerative capabilities to enhance their beauty. PRP has multiple applications for the aesthetic and the non-aesthetic world such as orthopedics and veterinary specialties.
Bioactive Molecules found in α- Granules of Platelets
- Growth factors
- Adhesive proteins
- Clotting factors
- Fibrinolytic factors
- Proteases and antiproteases
- Basic proteins
- Membrane glycoproteins
Platelet rich plasma is the processed clear plasma that is separated from the red blood cells from the patients' own blood. This platelet rich plasma is very rich in growth factors and is about 3-5 times more concentrated in these factors than unseparated blood. It is has been associated with enhancement in healing.
Growth Factors That Have Been Identified in PRP
- PD-EGF: platelet-derived epidermal growth factor
- PDGF-A & B: platelet-derived growth factor
- TGF-B1: transforming growth factor
- IGF I, II: insulin-like growth factor
- VEGF: vascular endothelial growth factor
- ECGF: endothelial cell growth factor
- bFGF: basic fibroblast growth factor
- CTGF: connective tissue growth factor
These growth factors send an attraction signal to dormant unipotent stem cells in the skin, and then stimulate a repair response, enhancing the growth of new younger skin cells. This results in activation of the desirable skin rejuvenation process.
Platelet Rich Plasma in the aesthetic world has captured interest for skin rejuvenation from head to toe. It can be used on the scalp for hair restoration, on the face body for a more youthful glow or for scar reduction to reduce post inflammatory hyperpigmentation and improve skin texture irregularities.
When we first introduced PRP in our clinic several years ago, we injected it with and without other tissue fillers, particularly, hyaluronic acids. When a patient requested it without tissue fillers, it meant injecting several spots throughout the face usually spaced 1cm apart. This resulted in severe down time due to bruising. When patients described the benefits they felt, they were willing to go through the process again, even if bruising occurred.
Fortunately, as the aesthetic world advanced and new procedures and techniques became available, combining PRP with these procedures made sense. One of our most popular procedures to use the PRP with is micro-needling. The other application that we have instituted is PRP after CO2 laser resurfacing. Micro-channels are made in the skin using the needling device or the factional laser. At the completion of the micro-needling or the fractional CO2, the plasma is placed directly on the area treated with micro-needling or fractional laser, which penetrated through the micro-channels. The plasma rich in growth factors then communicate with the stem cells and start the process of rejuvenation with the growth of new more youthful cells. This has provided us with a means to deliver the PRP without the prolonged bruising of multiple injections. Blunt cannulas used for tissue fillers can also be used to rejuvenate the skin to deliver the PRP into the skin with minimized risk of bruising.
Patients may appear to have mild sunburn immediately after the procedure. There may be pinpoint bleeding depending on the depth of treatment. This is usually not noticeable the following day. Partially due to the healing properties of PRP, there is minimal to no social downtime making this a very desirable option for patients. PRP can be used immediately after ThermiTight RF skin tightening (Injectable RF) procedure for the jowl and neck and other body parts to further enhancing the benefits of rapid healing and improved rejuvenation of a patient's own natural beauty. Adjuvant treatment with platelet-rich plasma is yet another advancement in the quest for efficacious skin treatment.